By Tung-Hu Tsai

ISBN-10: 0470409282

ISBN-13: 9780470409282

Discover new and rising purposes for microdialysis in drug evaluation

Microdialysis is a hugely beneficial sampling device that may be utilized in vivo to degree unfastened, unbound analyte concentrations positioned in interstitial and extracellular areas. This publication explores the total diversity of scientific purposes for microdialysis, concentrating on its use in several organ and tissue structures for pharmacokinetic and pharmacodynamic reports. Readers achieve an entire figuring out of the underlying technology of microdialysis, present innovations and practices, in addition to its many purposes in pharmaceutical research.

Applications of Microdialysis in Pharmaceutical technological know-how begins with an advent to uncomplicated ideas after which covers analytical concerns, pharmacodynamic and pharmacokinetic stories, medical facets, and designated functions. issues include:

  • Role of microdialysis in drug improvement, together with the most important sampling issues and functions for frightened process diseases

  • Continuous dimension of glucose concentrations in diabetics

  • Applications for scientific review and uncomplicated learn on organ platforms, together with tracking exogenous and endogenous compounds within the lungs

  • Pharmacokinetic and pharmacodynamic overview of anticancer drugs

  • Comparison of microdialysis with imaging techniques to guage in vivo drug distribution

  • Special purposes of microdialysis in experiences of phone tradition assays, drug-drug interactions, and environmental monitoring

Throughout the booklet, readers will locate basic types that make clear complicated thoughts and easy-to-follow examples that consultant them via key purposes in pharmaceutical examine. in brief, this publication permits pharmaceutical researchers to take complete good thing about microdialysis concepts for the preclinical and scientific overview of substances and masses extra.

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Additional resources for Applications of Microdialysis in Pharmaceutical Science

Example text

2005). Microdialysis for in vivo pharmacokinetic/pharmacodynamic characterization of anti-infective drugs. Current Opinion in Pharmacology, 5, 495–499. H. (2008). In vivo methods for the assessment of topical drug bioavailability. Pharmaceutical Research, 25, 87–103. R. (1989). Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood–brain barrier sites. Proceedings of the National Academy of Science of the United States of America, 86, 695–698. J. (2003). The role of drug transporters at the blood–brain barrier.

2008). Clinical microdialysis in skin and soft tissues: an update. Journal of Clinical Pharmacology, 48, 351–364. , Langer, O. (2006). Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution. AAPS Journal, 8, E263–E271. , Müller, M. (2005). Microdialysis for in vivo pharmacokinetic/pharmacodynamic characterization of anti-infective drugs. Current Opinion in Pharmacology, 5, 495–499. H. (2008). In vivo methods for the assessment of topical drug bioavailability.

M. (2005). In vivo microdialysis for PK and PD studies of anticancer drugs. AAPS Journal, 7, E659–E667. X. (1999). Use of intravenous microdialysis to monitor changes in serotonin release and metabolism induced by cisplatin in cancer patients: comparative effects of granisetron and ondansetron. Journal of Pharmacological and Experimental Therapeutics, 291, 960–966. , Dabrosin, C. (2003). Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo. Cancer Research, 63, 8742–8748.

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Applications of Microdialysis in Pharmaceutical Science by Tung-Hu Tsai


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