By Alan A. Boulton, Glen B. Baker, Roger F. Butterworth
To the Animal versions Volumes This and several volumes within the Neuromethods sequence will describe a couple of animal versions of neuropsychiatric problems. as a result of expanding public challenge over the moral therapy of animals in examine, we felt it incumbent upon us to incorporate this basic preface to those volumes so that it will point out why we expect extra - seek utilizing animals is important and why animal versions of psychiatric problems, particularly, are so vital. We realize that animals may still purely be used whilst appropriate choices are usually not on hand. we predict it self-e- dent, notwithstanding, that people can basically be experimented upon in significantly proscribed situations and substitute professional- dures utilizing cellphone or tissue tradition are insufficient in any types requiring tests of behavioral swap or of complicated in vivo approaches. despite the fact that, while the misery, pain, or soreness to the animals outweighs the expected profits for human welfare, then the study isn't really moral and shouldn't be performed. it really is principal that every person researcher study his/her personal examine from a serious ethical viewpoint - fore undertaking it, considering the animals’ welfare in addition to the predicted profits. in addition, as soon as a call to continue with examine is made, it's the researcher’s accountability to make sure that the animals’ w- fare is of top hindrance by way of applicable housing, feeding, and greatest relief of any uncomfortable or distressing results of the experimental stipulations, and that those stipulations suffer widespread formalized tracking.
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Extra info for Animal Models of Neurological Disease, II Metabolic Encephalopathies and Epilepsies
Rev. 37 (8), 1860–1874. , 2002. Harnessing the mouse to unravel the genetics of human disease. Genes Brain Behav. 1 (1), 14–26. , 2009.
An animal model is considered to have etiologic validity if the etiology of the behavioral changes (symptoms) studied in the model is identical to the etiology of the neuropsychiatric disorder. 19 the animal model, something that is not available in the majority of cases. However, etiologic validity can be assessed according to hypotheses on the etiology of disease, and if these hypotheses are later modified or refuted, assessments of the validity in the model would be adjusted accordingly. The concept of etiologic validity is especially important in testing hypotheses about genetic or environmental risk factors associated with psychopathology, in other words, when the overall objective of the study is to determine whether and how certain factors lead to disease.
Animal models of psychiatric disorders. J. ), Psychopharmacology—The Fourth Generation of Progress. Raven Press, New York, pp. 787–798. , 2000. The role of preclinical models in the development of psychotropic drugs. , Nemeroff, C. ), Neuropsychopharmacology—The Fifth Generation of Progress. Lippincott, Williams and Wilkins, Philadelphia, PA, pp. 445–455. , 2003. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636–645. , 2011. Animal models of obsessive compulsive disorder: recent findings and future directions.
Animal Models of Neurological Disease, II Metabolic Encephalopathies and Epilepsies by Alan A. Boulton, Glen B. Baker, Roger F. Butterworth